- Study observed over 10,000 women
- Tracing BRCA1 and BRCA 2 Carriers help in analyzing cancer risks in women
- Chances of breast and ovarian cancer found to be high at the 30s of a woman
- Chances of breast and ovarian cancer lowers in the 80s of a woman
- Family history plays an important role in tracing cancer
A recent study published in JAMA substantiates that cumulative breast cancer risk up to 80 years old found to be 72 percent in BRCA1 carriers and 69 percent for BRCA2 carriers.
BRCA1 and BRCA2 are human genes that produce a protein that repair damaged DNA or destroy those damaged cells in case DNA cannot be repaired. Tracing the mutations in BRCA1 and BRCA2 can predict the chances of breast and ovarian cancer in women.
In the new research conducted by a team of professionals led by Peter MacCallum Cancer Center, Australia, found that incidences of breast cancer in BRCA1 carriers increased rapidly from early adulthood to an age between 30 to 40 years and until 40 to 50 years in BRCA2 carriers. Meanwhile, the same incidences of breast cancer found to be constant at a rate of 20 to 30 per 1000 person from 50 years to 80 years in both BRCA1 and BRCA2 carriers.
The cumulative risk of ovarian cancer in BRCA1 carriers found to be 44 percent, and in the BRCA2 carrier, it is 17 percent. The study also reveals that if the first or second relative had been diagnosed with breast cancer, then the chances of the same too increases in BRCA1 and BRCA2 carriers.
The study included 11165 women with an average of 38 years for analyzing risks of breast and ovarian cancer. The researchers claimed that the information would be useful to understand the risks of breast or ovarian cancer in women by analyzing family history and mutations aspects.
Analyzing the research it is evident that the chances of breast or ovarian cancer were high when the woman reaches her 30s and it reduces when they get close to 80s.